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Hydroxocobalamin in Neo-B12 Injection is the precursor for the enzyme co-enzyme B12 and this reacts with the enzyme Methylmalonyl Coenzyme A mutase, an isomerase required for the conversion of methylmalonate to succinate, an important step in production of lipoprotein in myelin sheath tissue, which could cause neurological problems

Comprehensive safety studies spanning six months in rats (up to 100 mg/kg/day) and nine months in cynomolgus monkeys (up to 50 mg/kg/day) revealed no adverse findings, with NOAEL reaching the highest applied dosages

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MIC B12 Dosage Ranges Typically, MIC B12 injections can be administered 1 to 3 times per week

doi: 10.1007/s10620-008-0271-5, PMID: [DOI] [PubMed] [Google Scholar] 13.Koplay M, Gulcan E, Ozkan F

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