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PLoS ONE 7(1):e29641

Pickarts published work shows a roughly 60% decline by age 60 compared with people in their 20s

82 Overall, transcription factor binding site modification constitutes one of the crucial mechanisms for gene expression regulation, and its abnormalities may be linked to the emergence and progression of diverse diseases, including tumors

doi: 10.1038/bjc.2014.610 168 LiBXuAHuangYPengLXiangKLiQet al

The potency of carcinogens is determined by the ability to induce heritable alterations in the specific gene or by the stability of adducts formed with DNA (Klaunig and Kamendulis, 2004)