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Furthermore, double KO mice receiving three weekly intravenous injections of hCitrinmRNALNPs showed an increased preference for voluntary sucrose consumption, indicative of a reduction in the canonical aversion to carbohydraterich foods associated with CD [118]

Semaglutide Semaglutide is a novel long-acting GLP1 analogue indicated for T2DM and awaiting approval for obesity at higher doses

This dual approach is an interesting concept with the ability to not only successfully mediate the harsh microenvironment, but also induce regenerative repair to the damaged site

At the 12 mg dose level, here is what clinical trials reported: Nausea: 43.2% of participants (versus 10.7% on placebo) Diarrhea: 33.1% of participants (versus 13.4% on placebo) Constipation: 25.0% of participants (versus 8.7% on placebo) Vomiting: 20.9% of participants These percentages tell an important story