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MTHFR converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the cofactor form necessary for the re-methylation of homocysteine to methionine (see Figure 2 above)

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Severe overdoses can even result in toxicity

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In a solution containing sugar, B12 was degraded by about 30%, and in a solution containing iron, B12 was reduced by about 20%