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Multiplex immunofluorescence of these tumor tissues showed an increase in CD8 + T cells migrating from the stroma to the panCK+ tumor cell nests following ICT treatment, along with an increase in IFN in the tumor microenvironment (TME) and a concomitant enrichment in tumor cells expressing S100A9 and IFNGR1 (Fig

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Conversely, in reverse analysis, SZ was considered as the exposure variable, while LC and its derivatives were regarded as the outcome variables (Fig