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doi: 10.1038/s41598-024-59936-1 12 Al-DbassA

doi: 10.1016/j.jep.2022.115264 106 KassimMAchouiMMustafaMRMohdMAYusoffKM

Hypoxia is a significant angiogenic stimulus, as vascular smooth muscle cells proliferate and produce hypoxia-inducible factor-1 (HIF-1) in large quantities under hypoxic conditions

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Adrenarche also still occurs (except in those children with pituitary and subsequent adrenal failure), but development of secondary sex characteristics does not follow

This reduction lifts the inhibition on autophagy and triggers autophagosome formation, as evidenced by increased levels of LC3-II/I and Beclin-1, alongside a decrease in p62