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doi: 10.1038/nm.2415 15 NgSWKMitchellAKennedyJAChenWCMcLeodJIbrahimovaNet al

To learn more on the consequences of Stard7 deficiency in Wnt-driven tumor initiation on transcriptional reprogramming, we conducted RNA Sequencing experiments combined with GSEA with intestinal tumors from both Apc +/Min /Stard7 IEC and Apc +/Min /Stard7 Lox/lox mice

These findings suggest that autophagy is involved in several key pathologic aspects of RA, including pannus formation, synovial inflammation, and bone destruction