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The second mechanism involves the nuclear transcription factor NRF2 (nuclear factor erythroid 2-related factor 2), which governs the cell's antioxidant defense network

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Significantly, vitamin B12 concentrations imply the levels of vitamin B12 in the circulation, and higher levels of serum vitamin B12 may not be directly caused by a higher intake, instead the dysregulation of the metabolism of this vitamin may contribute to higher levels of vitamin B12 in the circulation

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