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Small molecule immunomodulins from cultures of the human microbiome member Lactobacillus plantarum

doi: 10.3389/fonc.2022.952290 67 LiuH.TangT

ROS have a significant effect on the sperm plasma membrane and subsequent functional integrity of the sperm resulting in a loss of acrosome reaction [11], the sperm potential for fertilization [12], sperm motility and vitality [13, 14] as well as impair the sperm capacitation [15] (Figure 1)

Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118

Clin Cancer Res 9(1):93-101, 2003

Exposing Bd to glutathione in vitro triggered a dramatic and sustained increase in zoospore production, indicating that glutathione, ubiquitous within host cells, may act as a cue to signal a favourable host environment