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The hypoxic environment of synovial tissue and mitochondrial damage are responsible for synovial inflammation and oxidative DNA damage, which increase the aggressiveness of FLSs (101)

Comp Biochem Physiol C Toxicol Pharmacol 229:108680

Abstract Nanozymes offer diverse therapeutic potentials for cancer treatment which is dependent on the development of nanomaterials

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However, the impact of other physiologically relevant metal ions on the anticancer activity and acquired resistance profile of thiosemicarbazones remains largely unknown(Ding and Lind 2009)