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When this complex reaches the duodenum, pancreatic enzymes release the B12, which then binds to intrinsic factor, a glycoprotein secreted by gastric parietal cells

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Yes, high-dose oral Vitamin B12 pills (usually 1000 to 2000 micrograms per day) are a highly effective alternative to lifelong intramuscular injections for most people with autoimmune gastritis or pernicious anemia [1] [2]

The most-cited study (Pyo et al

Oral bioavailability The fraction of an orally-administered dose of drug that reaches the systemic circulation and, as with bioavailability , abbreviated as F