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Arab JP, Sehrawat TS, Simonetto DA, Verma VK, Feng D, Tang T, et al

A larger change in sleep duration deviation across timepoints was associated with higher TSPO levels at T2 in all ROIs except for the frontal cortex (95% CI [0.00, 0.23]), indicating that individuals whose sleep duration deviated more from optimal sleep over the 5-year period (i.e., sleep duration that became short or longer than the recommended eight hours) had higher TSPO levels at T2 (adjusted for sex, age, retirement status, and TSPO gene (for gray matter) or gray matter volume of distribution (VT) (for all other ROIs)

References: [1] Cell Mol Life Sci

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Always take before photos to document progressclients often don't notice gradual changes until they see side-by-side comparisons