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While synergism and additivity allow for achieving better effects with lower drug concentrations, clinical data suggest that independent drug action can also significantly improve patient outcomes (69)

Assay of glutathione reductase In: BergmeyenHV, editor

The structure of Glutathione Glutathione (5-L-Glutamyl-L-cysteinylglycine) is synthesized by glutamate-cysteine ligase (GCL) and glutathione synthase (GSS)

Am J Respir Crit Care Med (2017) 195(6):80113

Nat Med 19:202208 Spicer J, Marabelle A, Baurain JF, Jebsen NL, Jossang DE, Awada A, Kristeleit R, Loirat D, Lazaridis G et al (2021) Safety, antitumor activity, and T-cell responses in a dose-ranging phase I trial of the oncolytic peptide LTX-315 in patients with solid tumors

References de Bie, P., Muller, P., Wijmenga, C