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Supplementary material The Supplementary Material for this article can be found online at: References 1 AkhlaghiniaB.MakaremA

Several studies have exposed that the long-term use of MPH induces the DA neuron loss and microglia activation causing an increase in pro-inflammatory markers TNF and IL-1, among others, resulting in the activation of neuroinflammation and triggering a neurodegenerative process [192, 193]