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Factors like low food intake, especially in vegetarians, malnutrition, and poor absorption due to gastrointestinal problems contribute to Vitamin B12 deficiency

Urine analysis, Kidney ultrasound, evaluation of immunoglobulin A levels, and kidney biopsy were suggestive of IgA nephropathy in the mentioned cases

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However, this has not been confirmed in controlled clinical trials

A deficiency of vitamin B12, therefore, results in reduced production and maturation of cells with high turnover particularly red blood cells

The compound's half-life is approximately 46 hours in rodent models, meaning plasma concentration peaks and declines within a predictable window