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Leptospira seropositivity as a risk factor for Mesoamerican nephropathy

This study in murine RAW264.7 macrophages revealed that 5-HT and its metabolites reduced oxidative stress and prevented the production of inflammatory cytokines by macrophages [103]

Alexander Herman Batelaan, senior, Deans List, College of Arts and Sciences, chemistry and mathematics

Combining pulldown experiments and functional assays to identify senolytic targets To identify the targets responsible for their senolytic activity, we synthesized two alkynylated derivatives of each compound, which we used to perform target identification in competitive, protein-directed activity-based protein profiling (ABPP) experiments (Fig