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Strategies are being developed to enhance delivery methods or produce analogs that mimic curcumin's neuroprotective properties [121]

Despite the early termination of the trial, it is interesting to note that 13 of 140 patients had a median duration of response of 10.2 months, indicating that these patients benefited from combination therapy and that exploring the mechanisms of this benefit should be the focus of future research

Consistently, mtDNA methylation generally shows a negative correlation with mitochondrial gene expression, but its precise consequences for mitochondrial function in preimplantation embryos remain to be clarified

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Meanwhile, BH4 could also reduce PLOOH pool by regulating the production of Ubiquinol (73)

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