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Acknowledgements We sincerely thank all colleagues and collaborators whose insights and discussions contributed to the development of this manuscript

1) Cortisol/Glucocorticoids Glucocorticoids/cortisol can increase the number of WBCs in the body [21]

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In Caucasian (white) skin, there is a specific group of polymorphic genes (with single nucleotide alterations) that encode for enzymes and transcription factors responsible for the early steps (including the first step, formation of L-DOPA from the amino acid tyrosine) of the melanin synthesis pathway

FTO The tumorigenic function of FTO in malignancies r was initially established in research on melanoma, wherein particular FTO variants were linked to an elevated risk of developing melanoma