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& Ecker, J

This observation led Fischer to speak of a dualism of porphyrins in nature, which is in essential agreement with present knowledge of the biosynthesis of the porphyrin isomers as proceeding along parallel and independent paths

2214 Distribution of fluoxetine and its metabolites into human body tissues and fluids has not been fully characterized

doi: 10.1016/j.physbeh.2021.113667 204

This has lead to the use of alternate velocity equations which do not use the kinetic constants kcat and Km at all, instead depending on a different rate constant, (Toppo et al., 2009)