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The MYC protein, which regulates both cell proliferation and chemoresistance in various cancers 39,40 , was expressed at high levels in the tumor and stromal compartments of the chemo-sensitive patients in the AMC NAC cohort

Another study suggest that the risk of nephrotoxicity increased with age, particularly in patients treated with cisplatin compared to carboplatin, due to the natural decline in nephron number and size with age, which makes older individuals more susceptibility to nephrotoxicity [65]

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It was noteworthy that oral L-theanine could also weaken the adverse reactions of S-1 adjuvant chemotherapy (75)