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Studies show that thiamine deficiency further inhibits PDH activity, accelerates M1 polarization, and exacerbates experimental colitis [452], while lactate dehydrogenase inhibitors can block this vicious cycle and partially restore immune homeostasis [452]

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The proton-motive force created by the ETC is also used for many additional mitochondrial processes, especially those related with transport across the IMM ( Although the primary function of mitochondria is to generate ATP as an energy molecule required for countless cell functions, a small fraction of electrons from the ETC are transferred directly to O 2 , resulting in the generation of the superoxide anion, which can give rise to other ROS as well as reactive nitrogen species (RNS)