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Salidroside, a natural phenylpropanoid glycoside isolated from Rhodiola rosea , has been shown to enhance mitochondrial complex I activity by upregulating and phosphorylating AMPK2, increasing cardiomyocyte tolerance to I/R injury and reducing ferroptosis

The cryoprotective efficacy of L-proline has been validated across species: in sperm cryopreservation, supplementation with 2 mM L-proline improved post-thaw motility, plasma/acrosomal membrane integrity, and antioxidant capacity and reduced Caspase-3/-9 levels in goat sperm while increasing proline dehydrogenase 1 (PRODH) protein expression (Zhang et al., 2022)

The results indicated a significant upregulation in the mRNA and protein expression levels of HK2 following I/R treatment

K.DasG.FracetoL

How Glutathione Works Glutathione helps neutralize free radicals, thereby reducing oxidative stress and inflammation

2.10 Cell lines and cell culture This study used the human epidermoid carcinoma cell line KB-3-1 as the drug-sensitive cell line, and its MRP1-overexpressing cell line KB/CV60 (Supplementary Figure S1A), which was maintained in the medium with 1 g/mL of cepharanthine and 60 ng/mL of vincristine (Supplementary Figure S1B) by transfecting recombinant pcDNA3.1/MRP7 plasmids and the parental human ovarian adenocarcinoma cell line SKOV3 (Wang et al., 2021b) were also used