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Perspective: targeting the jak/stat pathway to fight age-related dysfunction

Under healthy conditions, the host immune system efficiently prevents bacterial translocation by preserving intestinal barrier integrity, modulating microbiota balance, and regulating inflammatory responses

This dual regulation of SLC7A11 expression and activity creates a fine-tuning mechanism to modulate cell antioxidant capacity and lipid ROS during ferroptosis ( (with erastin, sulfasalazine, or sorafenib) or GPX4 (with RSL3, ML162, ML210, FIN56, or FINO2) can produce ROS in the absence of GSH depletion and trigger ferroptosis

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LRRK2 is located mainly in the cytoplasm, although approximately 10% of LRRK2 is located to the mitochondria and regulates mitochondrial function ( LRRK2 mutations in DA neurons were associated with an increased susceptibility to oxidative stress ( VPS35 Vacuolar protein sorting 35 (VPS35), composed of 796 amino acids, is a core component of the retromer complex and participates in endosomal-lysosomal transport