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Clinical and subjective measures Depression Depressive symptoms were assessed with the clinician-rated MontgomeryAsberg Depression Rating Scale (MADRS) as the primary measure, together with the self-report Quick Inventory of Depressive SymptomatologySelf Report (QIDSSR) and the Maudsley 3-item Depression Visual Analogue Scale (M3VAS)

Reynolds MR, Lane AN, Robertson B, Kemp S, Liu Y, Hill BG, Dean DC, Clem BF

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Purchasing them from unregulated sources carries a high risk of receiving impure, mislabeled, or contaminated products

This microglia produces chronic inflammatory mediators associated with neuroinflammation and parainflammation

Recently, specific inhibitors of ACSL4 and research on its upstream transcriptional regulators such as SP1 have shown clear cartilage-protective effects in OA models, suggesting that future strategies combining GPX4 modulation to enhance defense with ACSL4 inhibition to reduce attack may achieve more potent and synergistic therapeutic outcomes (He W