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Description

These pathways are typically assessed using phosphorylation assays, metabolic flux analysis, and gene expression profiling in adipose and related tissues

Preclinical studies suggest good tolerability, but comprehensive human trials are needed to establish safety profiles

Inhibition of NNMT rebalances cellular methyl economy and NAD salvage flux, with downstream effects on adipocyte energetics, lipid handling, and insulin action observed in preclinical systems [13]