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However: No large, peer-reviewed human trials exist demonstrating proven benefit

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Neither patient showed any laboratory or clinical evidence of vitamin B12 deficiency or hypothyroidism (which can cause B12 deficiency)

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ATG9, a transmembrane protein found in vesicles that originate from the trans-Golgi, endosomes or even the plasma membrane, is recruited to the PAS together with ULK1 and has been implicated as a seed for the initial establishment of membrane contact sites in yeast (52) and mammals (53, 54) ( Figure 1 , panel 2)