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The chronic administration of different doses of ferric chloride for thirty days resulted in a dose dependent and significant decline in the GSH concentration when compared to untreated control ( Table 1 and Figure 1 )

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These precursors are cleaved by the cytosolic cysteine protease caspase-1 into their active forms before being released into the extracellular environment [126]

mtDNA released into the cytoplasm and extracellular environment triggers various pattern recognition receptors and innate immune responses, such as cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING), TLR9, and inflammasome assembly [8, 9]