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demonstrated that 60.6% of children with new onset diabetes were positive for autoantibodies directed towards deamidated IA-2ec compared to 19.3% positive to the wild type IA-2ec, while only 14.2% of adults with T1D and 4.1% of patients with Latent autoimmune diabetes of adults (LADA) showed autoantibodies towards deamidated IA-2 compared to 8.8% and 1.5% to the wild type IA-2ec, respectively (126)

Enhancing the lipid peroxidation with ML162 led to decreased fusion rate and increased debris rate (Fig

Different regions apply varied regulatory frameworks, which can lead to inconsistencies in testing protocols, safety thresholds, and manufacturing requirements [246]