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In rare cases, allergic reactions can happen

Resistance It is known from a disease called diabetes mellitus, that there can be resistance to the actions of the hormone insulin the main regulator of blood glucose concentrations in many individuals

A 2014 study involving 976 subjects reported similar results (2)

Prolotherapy is particularly effective for: Ligament laxity and instability (knees, ankles, shoulders) Tendinopathies and tendon tears Chronic low back pain from ligament weakness Joint instability Sacroiliac joint dysfunction Conditions that have failed to improve with other conservative treatments PRP (Platelet-Rich Plasma) Therapy PRP therapy uses a concentrated preparation of the patients own blood platelets drawn, processed, and re-injected into the damaged area

Washington (DC): National Academies Press (US)

PMC 1499627