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2.3 Exogenous influences on oxidative stress and prostate cancer pathogenesis Studies have shown that the majority of PCa patients are diagnosed after the age of 65, with the risk of developing PCa significantly increasing in older individuals [35]

Research Applications Within controlled laboratory environments, glutathione may be utilised in experimental models designed to investigate intracellular antioxidant systems, biochemical signalling pathways and cellular regulatory mechanisms

Glutathione works by inhibiting tyrosinase, an enzyme responsible for melanin production

Glutathione may influence skin brightness, elasticity, and hydration, though results across studies are mixed

Additionally, in oxidative stress cells, Tripartite Motif Containing 22 (TRIM22) has been found to interact with Keap1 and accelerate the ubiquitination and degradation of NRF2, thereby inhibiting oxidative stress progression and activating ROS/AMPK/mTOR/autophagy signaling pathways

doi: 10.1002/jcb.25017 62 WangZ