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doi: 10.1136/bmj.315.7109.629 29 HajeMNaoomK

Kent and Vikesland, 2016

An increase in endogenous p62, either due to a defect in autophagy or as a result of its ectopic expression, sequesters KEAP1 into aggregates, hence causing inhibition of KEAP1-mediated NRF2 ubiquitination and degradation (43)