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In many aspects, it mimics human chronic disease associated with toxic damage

Endogenous DSIP has been detected in various brain regions, plasma, and peripheral tissues, though its concentrations are very low and its physiological fluctuations are not well-characterized

doi: 10.2337/dc19-0217 104 OldfieldLEvansARaoRGJenkinsonCPurewalTPsarelliEEet al

Sperm DNA fragmentation testing: summary evidence and clinical practice recommendations

However, as the overexpression of MUP1 and MMP1 appears to also decrease cytosolic acidification of CYS4 -OE cells (Supplementary Figure 1A), their action may also involve other molecular mechanisms