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One possibility is that autophagy suppresses apoptosis, as activation of autophagy can enhance sperm motility, reduce the expression of mitochondrial outer membrane translocase TOMM20 and PINK1, and inhibit the activation of Caspase 3 and 7, thus reducing apoptosis and promoting cell survival [201]

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4 At one time, these earlier named diagnoses were thought to represent distinct entities, but subsequent studies finding broad overlap of these older named conditions within families demonstrated that they were the same entity