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A recent meta-analysis of all the double-blind, placebo-controlled, randomized clinical trials of N-acetylcysteine as adjunctive therapy in bipolar depression confirmed its superiority over placebo in reducing depressive symptoms with a moderate effect size (95% confidence interval 0.060.84) [61]

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When compared to the vehicle control, transcranial application of P2RY12 or P2RX4 receptor antagonists impeded the ability of microglia (green) to assume both honeycomb and jellyfish morphologies, whereas P2RY6 antagonism blocked the formation of jellyfish processes only