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In further investigations, alcohol has been reported to significantly increase endotoxin levels and upregulate inflammatory cytokines like toll-like receptor 4 (TLR4), interleukin-6 and tumor necrosis factor [123], promoting the activation of myosin light chain kinase in IECs and further resulting in intestinal inflammation and increased permeability [124]

Additionally, by raising glutathione (GSH) levels and concurrently raising GPx and SOD1 activity after injury, CBD reduces hippocampus oxidative damage during oxygen-glucose deprivation/reperfusion injury (95)

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In addition, abundance of the LaeA-like protein VipC (AFUA_8G01930) was shown to be increased under basal conditions (log 2 1.23 fold increase) and further enhanced when exposed to 3 mM H 2 O 2 (log 2 2.5 fold increase) (Supplementary Tables S1 and S2)