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Ipamorelin hits the GHRP receptor and says "release GH now." CJC-1295 (no DAC) hits the GHRH receptor and says "amplify that release." When dosed together: CJC-1295 primes the pituitary and increases the available pool of GH Ipamorelin triggers the acute release of that pool The combined pulse is substantially larger than either compound generates alone research suggests synergistic effects in the range of 210x depending on baseline GH status and dosing This works because the two compounds bind to completely separate receptors

References Arias, N., Mendez, M

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Nature 447(7146):864868 Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I et al (2019) FSP1 is a glutathione-independent ferroptosis suppressor

B12 Shots vs Supplements Vitamin B12 Injections deliver a concentrated dose of B12 directly into the bloodstream, bypassing the digestive system entirely

doi: 10.1016/j.envres.2015.05.007 107 ParksCGWalittBTPettingerMChenJCde RoosAJHuntJet al