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Ferroptosis can contribute to the manifestations of RILI, with IR inducing mitochondrial shrinkage, iron accumulation, ROS, and lipid peroxidation generation, and expression of ferroptosis-related genes [56, 71, 73]

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Induction of these chaperones represents an adaptive stress response that protects cardiomyocytes by stabilizing the contractile apparatus and preserving sarcomeric organization during ischemic injury

Foods like meat, fish and dairy are the best source for B-12, but it can be created synthetically in a lab for supplements

On the other hand, the p75 NTR receptor has been reported to either induce or prevent apoptosis upon oxidative insult in both in vivo and in vitro models

Knock out of ALCAT-1, an enzyme that promotes cardiolipin peroxidation protected against onset of cellular senescence and preserved mitochondrial function by reducing sensitivity to lipid oxidation