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In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself

Further studies are needed to clarify the relative antioxidant power and role in microbiota maintenance of glutathione, ascorbic acid, uric acid, proteins, including glutathione-associated enzymes (glutathione-S-transferase (GST) and glutathione peroxidase (GPX)), alpha-tocopherol 38 , beta-carotene 38 and gut bilirubin derivatives (urobilin, stercobilin and protoporphyrin) 39 in the gut

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Short-term use of non-benzodiazepine sedative medications or sleep hygiene interventions may be considered to support sleep during withdrawal, but long-term use is discouraged due to dependency risks