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Some patients report pain relieving effects for several months following the injections.If the injections are effective they may be repeated after a period of time, usually 6 months.

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Throughout the experimental period, animals were monitored daily for signs of distress, including severe lethargy, impaired mobility, abnormal posture, or inability to access food and water

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While there is extensive knowledge of the interplay of core clock proteins in the central control of the sleepwake cycle, our understanding of how peripheral clocks regulate metabolism and health remains limited

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