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Furthermore, PKA phosphorylates and regulates the activity and expression of the cAMP-response element modulator (CREM) protein family, a group of transcription factors playing an important role in various cellular functions (82)

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Three of the sequences are very similar to each other (~96% sequence identity) and may represent transcripts derived from different homeologous alleles of the same gene (Figure S4)

STAT3 and STAT5 have been reported to act by inhibiting the antitumor immune response by activating, at least in part, the production of inflammatory cytokines (IL-1, IL-17, IL-10, TGF-, or VEGF) and promoting tumor growth and metastasis (150)

PMID: 40494050 Brain Behav A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm

While curtailing lactate mitigates lipid peroxidation, sparing membranes from 4-HNE assault, it risks starving cells of ATP in regions where mitochondria are irreparably damaged [210]