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IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2

However, upon nutrient deprivation or induced autophagy, their numbers can drop below 50 in a cell

Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, et al

Therefore, optimizing support at the cellular level becomes increasingly important

A reasonable bar would be at least one phase 2 RCT in a clinically relevant population (cognitive impairment, mild Alzheimer disease, post-stroke recovery, or similar) showing clinical efficacy with acceptable safety