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Mitochondria are highly dynamic organelles that serve not only as the primary producers of cellular energy, but also as metabolic hubs that rewire nutrient sensing and metabolic pathways, including aerobic glycolysis, glutaminolysis, pentose-phosphate pathway (PPP) activity, and one-carbon metabolism (Han et al, 2023)

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1 In studies of cells in culture and in animals IGF-1 has been shown to have remarkable effects on the spinal cord motor neurons

the disclosure includes embodiments in which exactly one member of the group is present in, employed in, or otherwise relevant to a given product or process

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