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One study found that serum miR-122 was upregulated 7.2-fold in patients with MASH compared with healthy subjects and 3.1-fold compared with patients with simple steatosis

10.1038/s41590-022-01354-4 75 JiaoY.ZhangT.LiuM.ZhouL.QiM.XieX.et al (2023)

Therefore, studying the mutant pir1 is significant for elucidating lesion mimic genes and the interdependent regulatory mechanisms between closely associated functional genes

Moreover, in both MT1-2 germline KO mice, it has been reported that zinc and MT1-2 are required for bone growth and MT3 is upregulated in the absence of MT1-2 [31]

Moreover, the positive effects of vitamin E supplementation in the treatment of NASH have been documented in several clinical trials 19,20

Ferroptosis was also induced by targeting myoferlin and mitochondrial iron metabolism, which promoted mitophagy [112]