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In the brain, glutamate can be directly synthesized de novo by astrocytes or indirectly produced from glucose molecules through the actions of pyruvate dehydrogenase and astrocyte-specific enzyme pyruvate carboxylase (Krzyanowska Pomierny et al., 2014

I have also included oral folate supplements, probiotics and have expanded my diet (but still excluding caffeine, alcohol and sugar)

Chem , 37 , 15011507

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Early studies established the amino acid and structural differences among the various apoE isoforms and advanced our understanding of the roles of apoE in various metabolic pathways

Accordingly, administration of milrinone, a PDE III inhibitor, to Wistar rats before noise over-exposure, ameliorates vacuolization, inflammation, and apoptotic processes in the sensory epithelium and the SV as compared to untreated rats (Ceylan et al., 2019)