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While brain interstitial fluid tau concentrations are reported to be nearly twice as high during the active period of the rest-activity cycle in humans [8], it is noteworthy that, to the best of our knowledge, no study has investigated whether the deletion of core clock genes, simulating circadian disruption, leads to an increase in tau hyperphosphorylation

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Such a possibility deserves further attention

All four work together

Cp m v lm mm da : Gip duy tr m cn thit cho da, mang li cm gic mm mt, d chu

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