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although this is uncommon, any history of hypersensitivity to niacinamide or NAD would be a contraindication

with proper maintenance, this lifespan can be extended even further

However, it is left to the manufacturer to assess their product, its manufacturing process and establish an acceptable action limit of contamination and stay within the limits for the water system based on the highest risk product manufactured with water

The effect has been shown as early as 3 months after starting the drug [47]

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