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Importantly, of all the metabolites that significantly distinguished +ADT from ADT group, the only metabolite that significantly correlated with PROMIS-SRI sleep impairment T -scores was androsterone sulfate, which is a metabolic endpoint marker of the effectiveness of ADT in reducing circulating androgens ( via alterations in the androgenic action on SCN circuitry and circadian rhythmicity

*Correspondence: Holger Prokisch, [email protected] This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Genetics Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi:10.1073/pnas.190353897

& Gilja, O

Trends in Endocrinology and Metabolism, 25 (5), 255262