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Therefore, in cell types with large amounts of endogenous G6PD, the apparent dynamic range of the sensors response may be reduced

This mechanistic action directly addresses the bioenergetic inefficiency observed in ME/CFS and Long COVID, helping to restore baseline cellular energy levels and potentially raising the threshold for post-exertional malaise (PEM)

Dipasquale D, Basiric L, Morera P, Primi R, Trscher A, Bernabucci U

We also highlight the in vivo importance of Set7/9 in ROS-related diseases

Although the propargylamine moiety might be responsible for the protection afforded by clorgyline and l -deprenyl, the lack of any protective effect of pargyline in our system and in some other neuronal models (see Mytilineou et al, 1997) would indicate it not to be a general property of all propargylamine derivatives

Mulder, D