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You take metformin or a proton pump inhibitor, which can deplete B12 over time

Research suggests 5-Amino-1MQ produces more targeted effects on adipose tissue metabolism, while NMN/NR provide broader systemic NAD+ elevation

In fact in the US the Centers for Disease Control (CDC) and the Institute of Medicine recommend B12 supplements for everyone over 50 years old

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The Increlex label explicitly contraindicates use in patients with active or suspected neoplasia and notes that active or suspected malignancy should prompt discontinuation

Neurological complications (injury to sciatic nerve) including paraesthesias and numbness have been described but are rare