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doi: 10.1038/s41565-023-01346-x 22 CaoH.DiaoJ.LiuH.LiuS.LiuJ.YuanJ.et al

These effects are believed to be related to the broader systemic benefits of optimized GH circulation on brain function and hormonal balance

More specifically, KEAP1 homodimerizes [124], binds to the ETGE and DLG motifs on Neh2 domain of NRF2, and also acts as a substrate adaptor protein [154] for the KEAP1-NEDD8-CUL3-RBX1 E3 ubiquitin ligase complex [119, 120, 155]

Regarding time course, 58 subsequent FF (22.9%) were sustained within the first 6 months, 42 between 612 months (16.6%), 72 between 1224 months (28.4%) and 81 occurred 2 y after index FF (32%)